One of the challenging cases in nephrology is managing a patient with severe hyponatremia, where each decision seems precarious. Overcorrecting sodium levels increases the risk of osmotic demyelination, while undercorrection leaves patients susceptible to complications. Nephrologists thread the needle carefully, focusing on avoiding overcorrection, typically aiming for a 24-hour correction rate below 6 to 8 mEq/L, or even lower at 4-6 mEq/L in patients with alcoholism, liver

One of the more challenging consultations in nephrology is evaluating a pregnant patient beyond 20 weeks’ gestation who presents with worsening proteinuria, high blood pressure, and increasing serum creatinine. In these situations, I am faced with deciding whether the findings show preeclampsia or the unmasking or progression of underlying chronic kidney disease (CKD). Preeclampsia often follows a more aggressive course and, in severe cases, may necessitate early delivery. In

I have often seen patients with chronic kidney disease who have an abnormal serum protein electrophoresis (SPEP) or free light chain (FLC) ratio and are referred to hematology before a nephrology evaluation. Many undergo an extensive hematologic workup, including a bone marrow biopsy, before their kidney disease is assessed. If the biopsy is negative for multiple myeloma or other hematologic malignancy, the abnormal monoclonal studies are attributed to monoclonal gammopathy o

As a nephrologist, I frequently see patients with kidney stones, and one finding that appears with striking regularity on metabolic evaluations is hypocitraturia, defined as urine citrate <320 mg/day. In large-scale urine studies, hypocitraturia is now the third most common metabolic abnormality in stone formers, surpassed only by high urine calcium (>250mg/day) and low urine volume (< 2 L/day), significant risk factors for kidney stone formation (1). Over the past two decade

Chronic Kidney Disease—Mineral Bone Disease (CKD-MBD) encompasses a spectrum of skeletal, vascular, and mineral metabolism abnormalities,...

Hyponatremia, a condition affecting 1 in 3 hospitalized adult patients, is a prevalent and significant electrolyte abnormality (1). It is...

More than a decade ago, as a new nephrologist in town, I approached diabetic kidney disease (DKD) with the assumption that proteinuria,...

Nodular glomerulosclerosis is a histopathologic finding on kidney biopsy characterized by nodule formation due to the accumulation of...

Membranous nephropathy(MN) is a renal limited autoimmune glomerular disorder and is the most common cause of nondiabetic nephrotic...

Primary hyperparathyroidism (PHPT) is a relatively common disorder affecting 85 per 100,000 men, with three times higher prevalence in...

Under normal circumstances, serum creatinine values are determined by its metabolic generation from the muscle, renal excretion, and, to...

Primary hyperparathyroidism (PHPT) is the most common cause of parathyroid mediated hypercalcemia (high normal or high PTH) while...

Kidney and renal pelvis cancer is the twelfth leading cause of cancer death in the United States (1). Renal cell carcinoma (RCC) accounts...